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糖尿病眼病实验室

  随着我国居民饮食结构和生活方式的改变,糖尿病视网膜病变的发生率逐年递增,已成为常见的致盲性眼病。据统计,目前我国糖尿病视网膜病变患者人数超过5000万,该疾病严重影响了病人的生活质量、增加了家庭和社会的经济负●!=昀矗臼笛槭易胖匚铺悄虿⊙鄄〉姆⒉』坪托碌闹瘟品椒ǹ寡芯俊
人员介绍:
负责人:李筱荣 教授

  实验室负责人李筱荣教授,中共党员,天津医科大学KOK足球APP医院院长、眼视光学院院长、KOK足球APP研究所所长。政府特殊津贴专家、教授、医学博士、博士生导师。自2003年至今,李筱荣教授承担了国家自然科学基金4项(其中3项已结题)、天津市科技支撑计划重点项目1项、十五攻关课题子课题1项,教育部博士点基金1项,美国米尔斯坦基金1项?翁饣竦霉式毕睿ǚ烂ぶ蚊し矫妫2次、天津市科技进步二等奖1项、天津市科技进步三等奖2项、天津市自然科学奖三等奖1项、中华医学科技奖三等奖1项,天津医科大学科技成果奖2项。以通讯作者身份发表专业论文220余篇,包括SCI文章45篇(均通讯作者),在KOK足球APP学基础研究最高影响因子杂志IOVS作为通讯作者发表3篇论文;国家级专利6项;主编、副主编、参编专著25部,2016年作为国家卫计委“十三五”本科规划教材《眼病学》主编,2010年作为副主编参与编写《眼病学》教材。自1998年至今,共指导硕士研究生58人,博士研究生19人,博士后2名,目前均已顺利出站。
近3年发表的代表性论文:
1.Li W, Ma M, Hu B, Dong L, Li X*. Spontaneous resolution of bilateral central retinal vein occlusion with cystoid macular oedema during pregnancy. Acta Ophthalmol. 23 November 2016 doi: 10.1111 / aos. 13213.
2.Pingting Zhao, Lingjun Zhang, Hui Shao, Lingling Bai, Bo Yu, Chang Su, LIjie Dong, Xun Liu, Xiaorong Li*, Xiaomin Zhang*. Therapeutic effects of mesenchymal stem cells administered at later phase of recurrent experimental autoimmune uveitis. Int J Ophthalmol. 2016 Oct 18;9(10):1381-1389.
3.Li W, Dong L, Ma M, Hu B, Lu Z, Liu X, Liu J, Li X*. Preliminary in vitro and in vivo assessment of a new targeted inhibitor for choroidal neovascularization in age-related macular degeneration. Drug Des Devel Ther. 2016 Oct 19; 10: 3415 – 3423.
4.Yu B, Shao H, Su C, Jiang Y, Chen X, Bai L, Zhang Y, Li Q, Zhang X*, Li X*. Exosomes derived from MSCs ameliorate retinal laser injury partially by inhibition of MCP-1. Sci Rep. 2016 Sep 30;6:34562.
5.Yingjuan Lv, Qingbin Yao, Wenjiang Ma, Hua Liu, Jian Ji and Xiaorong Li*. Associations of vitamin D deficiency and vitamin D receptor (Cdx-2, Fok I, Bsm I and Taq I ) polymorphisms with the risk of primary open-angle glaucoma. BMC Ophthalmol. 2016 Jul 19;16:116
6.Chen ZN, Shao Y, Li XR*. Radial optic neurotomy in treating central retinal vein occlusion: a Meta-analysis. Int J Ophthalmol. 2016 Jun 18;9(6):898-903.
7.Su L, Ren X, Wei H, Zhao L, Zhang X, Liu J, Su C, Tan L, Li X*. INTRAVITREAL CONBERCEPT (KH902) FOR SURGICAL TREATMENT OF SEVERE PROLIFERATIVE DIABETIC RETINOPATHY. Retina. 2016,36(5):938-943.
8.Zhang L, Li Y, Payne J, Srivastava S, Fan X, Fung J, Li X*, Kern TS, Lin F*.Presence of retinal pericyte-reactive autoantibodies in diabetic retinopathy patients. Sci Rep. 2016 Feb 3;6:20341.
9.Jin Yang, Bingcui Cai, Patrick Glencer, Zhiqing Li, Xiaomin Zhang, and Xiaorong Li*,Induced Pluripotent Stem Cells and Outer Retinal Disease. Stem Cells Int. 2016; 2850873. doi: 10.1155/2016/2850873. Epub 2016 Jan 5.
10.Su L1, Ren X, Wei H, Zhao L, Zhang X, Liu J, Su C, Tan L, Li X*. INTRAVITREAL CONBERCEPT (KH902) FOR SURGICAL TREATMENT OF SEVERE PROLIFERATIVE DIABETIC RETINOPATHY. Retina. 2015 Dec 1. [Epub ahead of print]
11.Chen Z, Shao Y, Li X. The roles of signaling pathways in epithelial-to-mesenchymal transition of PVR. Mol Vis. 2015 Jun 24;21:706-10.
12.Chen X, Shao H, Zhi Y, Xiao Q, Su Chang, Dong L, Liu X, Li X*, Zhang X*. CD73 pathway contributes to the immunosuppressive ability of mesenchymal stem cells (MSCs) in intraocular autoimmune responses. Stem Cell Dev. 2015 Dec 9. [Epub ahead of print]
13.Chen X, Huang H, Chen Y, Dong L, Li X*, Zhang X*. Achromatopsia Caused by Novel Missense Mutations in the CNGA3 Gene. Int J Ophthal. 2015;8(5):910-915
14.Ke Y, Wu Y, Cui X, Liu X, Yu M, Yang C*, Li X*. Polysaccharide hydrogel combined with mesenchymal stem cells promotes the healing of corneal alkali burn in rats. PLoS One, 2015 ,10(3):e0119725.
15.Yan Shao ,Li-jie Dong,Yan Zhang,Hui Liu,Bo-jie Hu,Ju-Ping Liu,Xiao Rong Li* Surgical induced astigmatism correlated with corneal pachymetry and intraocular pressure: transconjunctival sutureless 23-gauge versus 20-gauge sutured vitrectomy in diabetes mellitus. Int J Ophthalmol 2015, 8 (3): 528-533.
16.Dong L*, Nian H, Shao Y, Zhang Y, Li Q, Yi Y, Tian F, Li W, Zhang H, Zhang X, Wang F*, Li X*. PTB-associated splicing factor inhibits IGF-1-induced VEGF upregulation in a mouse model of oxygen-induced retinopathy. Cell Tissue Res, 2015 ,360(2):233-43.
17.Shi Y, Su C, Wang JT, Du B, Dong LJ, Liu AH, Li XR*. Temporal and spatial changes in VEGF, αA- and αB-crystallin expression in a mouse model of oxygen-induced retinopathy. Int J Clin Exp Med. 2015, 15, 8(3):3349-59.
18.Yuan LF, Li GD, Ren XJ, Nian H, Li XR*, Zhang XM*. Rapamycin ameliorates experimental autoimmune uveoretinitis by inhibiting Th1/Th2/Th17 cells and upregulating CD4+CD25+ Foxp3 regulatory T cells. Int J Ophthalmol. 2015,18;8(4):659-64
19.Zhang Y*, Bo Q, Wu W, Xu C, Yu G, Ma S, Yang Q, Cao Y, Han Q, Ru Y, Liu X, Wei RH, Wang FE, Zhang X, Li X*.α-Melanocyte-stimulating hormone prevents glutamate excitotoxicity in developing chicken retina via MC4R-mediated down-regulation of microRNA-194. Sci Rep.2015, 28(5):15812.

 
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